Effects of plitidepsin encompass angiogenesis, cell cycle arrest, apoptosis by caspase‐3, p38/MAPK, impairment of the eukaryotic elongation factor 1A2 (eEF1A2), subsequent PARP fragmentation, tumor stroma regulation, and sustained JNK activation as well 155, 158, 159. Here, MAPK8 is linked to neoplasm.