We explored whether HIV biomarkers moderated the relationship between subjective cognitive complaints and objective neuropsychological performance, but the results were statistically non-significant (CD4 T cell count [p=0.21], plasma HIV RNA [p=0.40], % undetectable at <50 copies/mL [p=0.36], AIDS status [p=0.84], current antiretroviral therapy status [p=0.69], duration of treatment [p=0.26]). This evidence concerns the gene CD4 and AIDS.