As mentioned above, Hsp60 is also involved in autoimmunity, it is tentative to speculate that mizoribine's activity on the Hsp60-Hsp10 complex or Hsp60 alone may also contribute to its immunosuppressive effect although supplementing GTP could reverse mizoribine's immunosuppressive effect (Turka et al., 1991). This evidence concerns the gene HSPD1 and Autoimmunity.