For example, hepatocyte growth factor (HGF), and transforming growth factor β (TGFβ) are known to enhance tumor cell proliferation and promote the acquisition of invasive phenotypes, such as epithelial-to-mesenchymal transitions (EMT) (Stoker et al., 1987; Miettinen et al., 1994; Bhowmick et al., 2004a). Here, TGFB1 is linked to neoplasm.