PNPLA3 and metabolic dysfunction-associated steatotic liver disease: More recently, a significant increase of serum AST activity and trends for increased ALT and GGT activities have been reported with the increment of risk alleles at 3 loci (rs738409 in PNPLA3; rs58542926 in TM6SF2; rs641738 in membrane bound O-acyltransferase containing 7, MBOAT7) in a German population of adult NAFLD patients [29].