Genotype distribution for the polymorphisms studied at the TM6SF2 and KLF6 loci showed a nonsignificant trend towards the reduction of wild-type CC homozygous and the increase of heterozygous carriers of the polymorphic T allele when moving from healthy controls, through noncirrhotic NAFLD, to NASH cirrhotics. Here, KLF6 is linked to metabolic dysfunction-associated steatohepatitis.