Based on the results of said selectivity screens, the observation of cytotoxicity in BET-dependent AML cell-lines above 1 μM and our FRAP dose-response experiments we recommend that, for cellular experiments, a dosage of 100–500 nM is optimal, to allow for total or near-total inhibition of L/V BET proteins while sparing the wild-type. Here, DNER is linked to acute myeloid leukemia.