VTCN1 and central nervous system cancer: Treg can induce the expression of B7-H4, a B7 family member protein, on MΦ and convey the suppressive signal to inhibit T-cell immunity.38Via western blotting and immunofluorescent staining observation, B7-H4 was greatly down-regulated in the glioma tissues from the mice receiving the T12/Man-BSA NPs (Fig. 7B and E), which indicated the immune suppression was lifted.