Of note, the reversal of TAM2 to TAM1 can increase CD8+ T cell infiltration.39 IFN-γ is a key cytokine secreted by CD8+ T cells for coordinating tumor immune responses and executing direct tumoricidal activity.40 It was found that with the treatment of the T12/Man-BSA NPs, an upregulating level of IFN-γ was determined in the glioma tissue (Fig. 7C). This evidence concerns the gene CD8A and glioma.