Similar to MALAT1, silencing of Survival Associated Mitochondrial Melanoma-Specific Oncogenic ncRNA (SAMMSON), an oncogene which confers a proliferative advantage in melanoma, with ASO gapmers reduced clonogenicity regardless of BRAF, NRAS, or p53 status elucidating to the addiction of melanoma cells to SAMMSON expression. This evidence concerns the gene SAMMSON and melanoma.