Imatinib- is used for CML(Chronic Myelogenous Leukemia) and ALL(Acute lymphocytic Leukemia) and other gastrointestinal stromal tumours(GIST).Lapatinib- Used in treatment-naïve, ER+/EGFR+/HER2+ breast cancer patients and patients with HER2-positive advanced breast cancer that has progressed after previous treatment to Trastuzumab, anthracycline and taxane derived drugs.Combinatorial Drug Therapy for Triple Negative Breast Cancer. This evidence concerns the gene ESR1 and breast carcinoma.