HOTAIR and cancer: Furthermore, lncRNAs can alter the activity of different hallmarks of cancer by either sustaining proliferative signaling (e.g. SRA), evading growth suppressors (e.g. ANRIL), inducing angiogenesis (e.g. MVIH), inducing invasion and metastasis (e.g. HOTAIR and MALAT1), inhibiting apoptosis (MEG3), or by enabling replicative immortality (TERC and TERRA) [23, 79–82].