The t(14;18) chromosome translocation, bringing the BCL-2 gene under the control of the immunoglobulin heavy chain enhancer is found in all B-cell follicular lymphomas [3, 4] and in approximately 30% of DLBCL [27] while BCL-2 gene amplification is commonly found in MCL and DLBCL [28]. This evidence concerns the gene BCL2 and diffuse large B-cell lymphoma.