S55746, currently in phase I clinical trials in heamatological malignancies (Trials registration ID: NCT02920697, NCT02920541 and NCT02603445) displays all the hallmarks of a BCL-2 specific BH3-mimetic and exhibits robust antitumor activity in BCL-2 dependent lymphoid tumor xenograft models while sparing platelets. The gene discussed is BCL2; the disease is lymphoid neoplasm.