In these 182 CRC detected in 25 patients, we found 18 different VHL mutations affecting the three exons of the VHL gene: seven are missense mutations that induce an amino acid change within the VHL protein in eight patients (26.7%), one is a silent mutation with no effect at protein level found in a single patient, seven are deletions causing frameshifts and three are nonsense mutations that generate premature stop codons and result in a truncated VHL protein for 16 patients (Table 1). This evidence concerns the gene VHL and colorectal carcinoma.