On the other hand, in intrahepatic cholangiocarcinoma (iCCA), a retrospective study showed that the level of CD8+ TILs inversely correlated with PD-L1 expression, and it was hypothesized that this result was due to PD-L1 expression acting as a negative regulator of T lymphocytes [43]. This evidence concerns the gene CD274 and intrahepatic cholangiocarcinoma.