TP53 and squamous cell carcinoma: However, in the squamous cell carcinoma patients, a clear association was found between higher nuclear p53 percentage and worse progression-free survival (p=0.031), with a median progression-free survival of 35.4 [22.7-48.1] months for patients with high nuclear p53 staining, while the median survival value was not reached in the group of patients with low nuclear p53 protein levels.