RELA and neoplasm: To further substantiate the role of NF-κB in mediating the cytotoxic effects of trabectedin in premature senescent tumor cells, we analyzed A549 and MCF-7 cells in which expression of RelA/p65 was knocked-down by small hairpin RNA (A2 and M2, respectively, Figure 6), as compared with scramble infected controls (ASCR and MSCR, respectively, Figure 6) [6].