Biologically, statins can potentiate the efficacy of anti-androgen treatments, such as abiraterone and enzalutamide, in mCRPC through a number of potential mechanisms, including: inhibition of intra-tumoral de novo steroid biosynthesis [17], inhibition of biosynthesis of isoprenoids [18], as well as inhibition of the organic anionic transporters (e.g., SLCO2B1) [19] that are responsible for adrenal androgen dehydroepiandrosterone (DHEA) influx into cancer cells [20]. The gene discussed is SLCO2B1; the disease is cancer.