The top five canonical pathways in NSCLC were PTEN Signaling, PI3K/AKT Signaling, Molecular Mechanisms of Cancer, Glioblastoma Multiforme Signaling, and Pancreatic Adenocarcinoma Signaling; in SCLC, the top five canonical pathways were Calcium Signaling, Purine Ribonuclease Degradation to Ribose-1-Phosphate, UDP-N-acetyl-D-galactosamine biosynthesis II, Regulation of the Epithelial-Mesenchymal Transition Pathways, and Xanthine and Xanthosine Salvage. This evidence concerns the gene AKT1 and cancer.