PXN in NSCLC is suppressed via ITGA5 and IGF1R downregulation, stimulatory effects of ABL1 upregulation does not affect resulting trend towards the gene suppression; in SCLC, suppression is achieved via downregulation of NRP1; therefore we should expect a higher level of PXN in NSCLC than in SCLC specimens. The gene discussed is NRP1; the disease is non-small cell lung carcinoma.