The development of NSCLC was associated with an increase of molecules associated with endoplasmic reticulum (ER) stress [28] - hsa-miR-3648 (up 2.08 folds) and TNF-α, IL-6 suppression [29] - hsa-miR-4488 (up 3.49 folds), and decrease of one that is known to regulate glioma cell invasiveness and the release of extracellular vesicles - hsa-miR-5096 (down 3.02 folds) [30–32]. Here, IL6 is linked to central nervous system cancer.