Fu et al. in our lab recently demonstrated PD-L1 immunohistochemistry (IHC) staining as an ancillary technique in distinguishing invasive EFVPTC from NIFTP and supported the reclassification of NIFTP [13, 14] even if the tumor size is more than 4 cm or the patients are older than 45 years of age [15]. The gene discussed is CD274; the disease is neoplasm.