Indeed, while these tumours showed high levels of H-RAS expression in comparison to adjacent normal tissue (Figure 4C, 4D) and were immunoreactive for the common mesenchymal marker VIMENTIN, the tumour cells did not stain for lineage markers including CD31, vWF, DESMIN, SMA, MYOD1 or MYOGENIN (Figure 3C, last column). This evidence concerns the gene DES and neoplasm.