In the context of the results of the present study, it might be possible in future long-term and large-scale studies to utilise multi-generational interbreeding strategies between C57BL/6 and Fox Chase CB17 strains, coupled with genomic analyses, to narrow down loci that contribute to the type of sarcoma that develops in response to oncogenic HrasG12V expression and Cdkn2a knockdown. The gene discussed is CDKN2A; the disease is sarcoma.