CTSB and neoplasm: Additionally, several matrix metallopeptidases [MMP1, MMP11, MMO14 and MMP2] as well as proteins involved in collagen metabolism [CTSB, CTSK, CTSL, CTSS] and immune responses (interleukins and C-X-C motif chemokine ligands) were downregulated in the immortalized cell line due to both perturbations further supporting a link between hypoxic response and tumor progression (Supplementary Tables 1 and 4).