PLTP functions are relevant for many pathophysiological alterations involved in the development and progression of neurodegenerative disorders (especially lipid metabolism, redox status, and immune reactions [20–22]), and a significant increase in brain PLTP levels, along with a decrease of its activity in the CSF were observed in patients with Alzheimer's disease (AD) compared to controls [19, 23]. This evidence concerns the gene PLTP and early-onset autosomal dominant Alzheimer disease.