PLTP and amyloidosis: Although the reason of the discrepancy between these observations and our findings is not clear at this time, it is worthy of note that their study was conducted in three month-old animals, which corresponds to a very early stage of the amyloid pathology where amyloid deposition has not appeared yet; moreover, as reported earlier for the membrane receptor TREM2 [37], there could be a stage-dependent differential effect of PLTP on the pathology.