PLTP-deficient mice were shown to display an anti-inflammatory phenotype (e.g. lower circulating levels of IL-6) [43, 44], and reduced expression level of IL-6 and infiltrating macrophages in aortic tissue of PLTP–/– mice as compared to wild type mice was recently observed in an experimental model of abdominal aortic aneurysm [45]. Here, IL6 is linked to abdominal aortic aneurysm.