Interestingly, at cut-off values >5% of the tumour cells with positive staining, the co-expression of EGFR/HER-2, EGFR/HER-3, EGFR/c-MET, and EGFR/HER-2/HER-3 were all associated with a poorer disease free-survival in the univariate analysis (Figure 2B, Table 4). This evidence concerns the gene ERBB3 and neoplasm.