While there was no significant association between CD44 immunostaining at cut-off values >5%, >10% and >20% and overall survival, CD44 immunostaining of 3+ intensity at cut-off values of >5% of tumour cells was associated with poorer overall survival in these patients (3.66 ± 0.39 vs. 5.01 ± 0.20) (p <0.0001) (Figure 2A). The gene discussed is CD44; the disease is neoplasm.