Consistent with the previous reports demonstrating that upregulation of the intrinsic apoptotic protein BIM was crucial to MEK inhibitor-mediated apoptosis in KRAS or BRAF mutant cancers [29, 30] we observed slight increases of BIM expression in cells co-treated with CH5126766 and statins compared with each single treatment (Figure 3C and 3D). This evidence concerns the gene BCL2L11 and cancer.