LCTL and cancer: The univariate analysis revealed that tumor grade, infiltration (INF) pattern, the presence of carcinoma in situ, the presence of LVI, and high KLγ expression was the predictive factors for the intravesical progression (hazards ratio [HR] = 3.0, 95% confidence interval [CI] 1.0-9.1; P = 0.05; HR = 6.6, 95% CI 2.5-17.4, P < 0.0001; HR = 2.8, 95% CI 1.1-7.5, P = 0.034; HR = 3.2, 95% CI 1.3-7.9, P = 0.014; HR = 3.6, 95% CI 1.2-10.9, P = 0.013, respectively).