MAPK3 and triple-negative breast carcinoma: Trošt et al. showed that, in patients with triple negative breast cancer, the expression level of KLγ was high and correlates with poor progression, that KLγ was a necessary factor for cell survival, and that depletion of KLγ resulted in cell cycle arrest, apoptosis, and persistent activation of the ERK1/2 signaling pathway [22].