In a gene therapy-based study, rat iPSC-MSC were genetically engineered with TNFα-stimulated gene-6 (TSG-6), to assess their potential to enhance the therapeutic effects of iPSC-MSC in experimental periodontitis, established by ligature and infection with P. gingivalis around the maxillary first molar bilaterally [24]. The gene discussed is TNFAIP6; the disease is periodontitis.