AKT1 and cancer: Akt signaling has been reported to play essential roles in the progression of many tumors, including osteosarcoma (Keremu et al., 2017; Liu et al., 2017; Ma et al., 2017), and the PI3K/Akt pathway participates in almost all malignant processes, including tumorigenesis, cancer cell proliferation, metastasis, angiogenesis, and chemoresistance (Yuan and Cantley, 2008; Berlanga et al., 2016; Dai et al., 2016; Davaadelger et al., 2016).