However, HFD-fed MKO mice showed lower fasting glucose and insulin levels (Figures 6C,D) and, therefore, improved insulin resistance as determined by homeostatic model assessment for insulin resistance (HOMA-IR) (Figure 6E), indicating that deletion of Lmna in macrophages improves obesity-induced systemic insulin resistance. Here, LMNA is linked to obesity due to melanocortin 4 receptor deficiency.