To explore if the peripheral CB1R antagonist LH-21 will be of benefit to the management of obesity-accompanied hypertension, and further to clarify the underlying mechanism, the impact of LH-21 on obesity-accompanied hypertension was investigated in KKAy mice, a polygenic mouse model of human obesity, T2DM, dyslipidemia, and hypertension (25–27). Here, CNR1 is linked to obesity disorder.