Importantly, human genome-wide association studies (GWAS) have identified DAB2IP, the gene for AIP1, as a susceptibility gene for early onset of myocardial infarction, abdominal aortic aneurysm, and peripheral vascular disease (Gretarsdottir et al., 2010; Harrison et al., 2012). This evidence concerns the gene DAB2IP and peripheral vascular disease.