Activation of the ACE2/Ang-(1-7)/Mas1 axis by the administration of ACE2 or Ang-(1-7) results in enhanced ACE2 activity and promotes expression of ACE2/Mas1 over ACE/AT1 in PF and PH; furthermore, augmentation of the ACE2/Ang-(1-7)/Mas1 axis improved the pathological symptoms associated with these heart and lung tissues (Shenoy et al., 2013; Meng et al., 2014, 2015). The gene discussed is ACE2; the disease is pemphigus foliaceus.