Activation of the ACE2/Ang-(1-7)/Mas1 axis with administration of either rhACE2 or Ang-(1-7) also improves the cardio-pulmonary defects associated with experimental PH and PF (Shenoy et al., 2010, 2013; Meng et al., 2015). This evidence concerns the gene ANG and pemphigus foliaceus.