More recently, we have observed that the pathological phospho-epitope pThr175 tau protein is also observed across a broad range of tauopathies, strongly suggesting that its presence in ALSci is not simply incidental, but rather a marker of a fundamental alteration in tau protein processing across a range of tauopathies (Moszczynski et al., 2017). Here, MAPT is linked to tauopathy.