MAPT and Alzheimer disease: While investigating evidence for this pathway in human disease, we observed the co-localization of pThr175 and pThr231 in tau protein NCI-containing hippocampal neurons in ALSci and a broad range of tauopathies including Alzheimer's disease, diffuse Lewy body dementia, and FTLD among others (Moszczynski et al., 2017).