The prominent deposition of tau protein, including pThr175 tau, has been subsequently validated in motor neuron disease (MND) and MND in the presence of a behavioral variant of FTD (bvFTD-MND), including the appearance of tau protein deposition in 10% of MND cases that did not conform to traditional morphological criteria (unclassified frontal tau protein) (Behrouzi et al., 2016). The gene discussed is MAPT; the disease is motor neuron disorder.