It is of note, therefore, that cis-pThr231 tau is closely associated with a number of tauopathies including, AD, CTE and experimental CTE (Lu et al., 1996, 1999; Liou et al., 2003; Pastorino et al., 2006; Sultana et al., 2006; Lu and Zhou, 2007; Lim et al., 2008; Lee et al., 2011; Chen et al., 2015; Kondo et al., 2015; Albayram et al., 2017). The gene discussed is MAPT; the disease is Alzheimer disease.