MAPT and amyotrophic lateral sclerosis: Given this suggestion of pathological tau protein phosphorylation in ALSci, we conducted a phospho-epitope analysis and identified a unique tau phosphorylation site at Threonine 175 (pThr175 tau) in ALS and ALSci that was not present in either control or AD (both soluble and insoluble tau protein isolates) (Strong et al., 2006).