MAPT and amyotrophic lateral sclerosis: Using a novel polyclonal antibody against pThr175 tau, we subsequently confirmed the presence of prominent tau protein glial and neuronal cytoplasmic inclusions in ALSci, and to a lesser degree in ALS without cognitive deficits, in association with an increase in the expression of active GSK3β (Yang et al., 2008; Yang and Strong, 2012) (Figure 1).