The in vivo observation of co-expression of pThr175 tau, pTyr216GSK3β, pThr231 tau, and immunoreactivity to a tau protein antibody recognizing oligomeric tau (T22) strongly suggests that this pathway is critical to the induction of pathological tauopathies, including ALSci, CTE and CTE-ALS (Moszczynski et al., 2017, 2018). The gene discussed is MAPT; the disease is amyotrophic lateral sclerosis.