Epitope specificity for the tau-pT123, tau-pT427 and TAOK-pS181 antibodies was confirmed by pre-treating these reagents with their appropriate phospho-peptides, which blocked antibody recognition of their target epitopes in immunostained AD sections and in immunoblotted in vitro kinase assays (Additional file 3: Figure S2A-B). The gene discussed is MAPT; the disease is Alzheimer disease.