The other major genetic locus linked to AMD is at chromosome 1q31, where a single nucleotide polymorphism (SNP) rs1061170 causes a missense mutation Y402H in complement factor H (CFH; Edwards et al., 2005; Klein et al., 2005; Hageman et al., 2005; Haines et al., 2005). Here, CFH is linked to age-related macular degeneration.