VEGFA and retinopathy of prematurity: However, in one condition, retinopathy of prematurity (ROP), an intravitreal injection of an anti-VEGF agent leads to high concentrations of the drug in the relatively small blood volume of the premature infant [6] and has raised concerns not only about inhibition of VEGF in the developing retina, but also about systemic inhibition of serum VEGF during organ system development in the premature infant [7].