VEGFA and retinal disorder: We approached the question of how to optimize anti-VEGF dose to safely inhibit retinopathy by specifically targeting upregulated VEGF in Müller cells in an experimental rat model of oxygen-induced retinopathy (OIR) that is highly representative of human ROP in that fluctuations in inspired oxygen cause a delay in physiologic retinal vascular development followed by intravitreal neovascularization (IVNV) and poor postnatal growth [12, 13], as seen in preterm infants with ROP.