The pituitary transcription factors LIM Homeobox 3(LHX3), SRY-Box 2 (SOX2) and HESX homeobox 1 (HESX1) are vital for early patterning of the forebrain and pituitary, and mutations in these developmental genes result in syndromic hypopituitarism with gonadotropin deficiency in humans (Kelberman et al., 2009). This evidence concerns the gene HESX1 and Gonadotropin deficiency.