Eguci and coworkers described a prevalence of 45% of ALT increase and of 4% of severe liver dysfunction in a cohort of 175 Japanese patients treated with methylprednisolone pulse therapy for Graves’ ophthalmopathy, but they included many patients with chronic HBV or HCV hepatitis (Eguchi et al., 2015). Here, GPT is linked to Graves ophthalmopathy.