Upon binding to DNA, Snail1 forms complexes with corepressor complexes containing the histone deacetylases HDAC1/2, the histone H3 methyltransferases G9a and Suv39H1 and DNA methyltransferases, all enforcing transcriptional shut off, repressive chromatin conformation and even DNA methylation at the target gene, such as CDH1, during breast cancer EMT (Dong et al., 2012, 2013a; Peinado et al., 2004). This evidence concerns the gene SNAI1 and breast cancer.