SNAI1 and kidney disorder: In a similar mechanistic scenario, Snail1 expression and induction of EMT also contributes to organ fibrosis as is the case of renal disease; Snail1 expression promotes renal EMT and generation of myofibroblasts with contractile features similar to those of CAFs, whereas suppression of Snail1 reverts the fibrotic phenotype in experimental mice where Snail1 expression can be switched on and off (Grande et al., 2015).