SNAI1 and breast carcinoma: Among the 639 genes whose expression changed significantly upon knockout of Snail1 (Fig. 6), we paid further attention to two specific regulators of bone homeostasis because triple‐negative breast cancer cells often metastasize to the human skeleton and form osteolytic lesions (Nguyen et al., 2009), but more importantly because these two genes were regulated in an opposite manner, and Snail1 could associate with their respective genomic regulatory sequences (Fig. 4).