However, no significant difference in SOCS4 expression was observed between HBx transgenic and non‐transgenic livers at the time point of tumor formation post‐PH, although SOCS4 expression was significantly downregulated in the age‐matched 12‐month‐old non‐PH transgenic livers compared with non‐transgenic livers. This evidence concerns the gene SOCS4 and neoplasm.