The fact that oligomenorrheic PCOS shows higher kisspeptin pulse frequency but similar LH pulse frequency than eumenorrheic PCOS, let us infer that, as putative causal factor, also a neuroendocrine impairment might occur at the level of kisspeptin receptors and/or signal transduction on GnRH secreting neurons. Here, PLOD1 is linked to polycystic ovary syndrome.