Moreover the subtle but relevant differences inside the PCOS patients group (according to the eu-or oligomenorrheic condition) might reflect the deteriorating of the kisspeptin-GnRH axis functioning, thus leading to an impaired neuroendocrine function of the reproductive axis, as previously reported [24], though those with regular ovulatory cycles (and intermenstrual interval < 45 days) still show normal LH pulsatile patterns both in terms of amplitude and frequency [25], as our oligomenorrheic patients. This evidence concerns the gene PLOD1 and polycystic ovary syndrome.