Notably, STAT3 can also be methylated on Lys49 and Lys180 by EZH2, the lysine methyltransferase subunit of the polycomb repressive complex 2 (PRC2) in glioblastoma, colon cancer, and breast cancer cell lines [52, 53] (Fig. 5d). Here, STAT3 is linked to malignant colon neoplasm.