UCHL1 and Parkinson disease: To dissect the contributions of global (chemical and thermal) folding stability and folding topology to the mechanostability of UCHs, we generated two ssrA-tagged UCHL1 variants harboring a Parkinson’s disease (PD)-associated I93M mutation (UCHL1I93M)43,44, or a naturally occurring truncation of the first eleven residues at the N-terminus (UCHL1∆11)45.