NPPB and cardiovascular disorder: As NPs, particularly ANP and BNP, are known to exert cardio-protective effects countering the deleterious pathological consequences arising from activation of the RAAS and sympathetic nervous systems in cardiovascular disease states, our results suggest that induction of miR-143 may potentially be exploited for therapeutic manipulation of the bioactivity of circulating and /or tissue based cardioprotective NPs.