Moreover, the commonly upregulated oral cancer specific miR-181a-3p which does not have interaction site with OIP5-AS1 remains upregulated (P = 0.0319) in undifferentiated tumors suggesting that the other miRNAs might be tightly regulated by overexpressed OIP5-AS1 through its sponging activity. This evidence concerns the gene OIP5 and lip and oral cavity carcinoma.