Interestingly, all the 3 lncRNAs were upregulated in the oral tumors that overexpressed OIP5-AS1 and showed significant positive correlation with OIP5-AS1 expression (HOTAIR – r = 0.678, TUG1 – r = 0.645 and NEAT1 – r = 0.346) in TCGA HNSCC datasets (Figs. 4d,e). This evidence concerns the gene HOTAIR and head and neck squamous cell carcinoma.