Although this indicates that COL6A1 expression might be a diagnostic marker for tumor progression, as its increased expression is a hallmark of high-grade gliomas, further studies pointed at COL6A1 as a prognostic marker, because it is also associated with poor clinical outcome in grade IV glioblastoma multiforme (Turtoi et al., 2014). This evidence concerns the gene COL6A1 and glioma.