COL6A2 and brain neoplasm: Additionally, COL6A2 expression was also reported to be associated with high-grade astrocytomas (Boon et al., 2004), and gene expression profiling showed that both COL6A2 and COL6A3 are upregulated in pediatric brain tumors, including pilocytic astrocytoma, ependymoma, medulloblastoma and glioblastoma multiforme (Di Rosa et al., 2015).