LOXL2 and hepatocellular carcinoma: MHCC97H and Hep3B cells grown on 10, 16 KPa stiffness substrate exhibited an extension and expansion morphology, different from small round shape on 6 KPa stiffness substrate (Fig. 2a). Morphological alteration perhaps means a great change in their malignant characteristics. To confirm LOXL2 expression level in vivo, we further applied a HCC tissue microarray established previously [16] to analyze the effect of liver matrix stiffness on LOXL2 expression.