Besides, CM-LV-LOXL2-OE as chemoattractant increased the number of migrated HCC cells, and improve the expression of chemokine CXCL12 in lung fibroblasts, suggesting that the secreted LOXL2 also facilitated the motility ability of HCC cells and strengthened CTCs settlement on the remodeled matrix “soil”. Here, LOXL2 is linked to hepatocellular carcinoma.