Except the above results, we also found that CM-LV-LOXL2-OE as chemoattractant increased the number of migrated HCC cells (Fig. 5e), and improve CXCL12 expression in lung fibroblasts (Fig. 5f), revealing that the secreted LOXL2 also facilitated the motility of HCC cells and strengthened CTCs settlement on the remodeled matrix “soil”. The gene discussed is CXCL12; the disease is hepatocellular carcinoma.