It has yet to be determined if angioedema attacks in patients with HAE due to a novel plasminogen mutation (HAE-PLG), HAE with a novel angiopoietin-1 gene mutation (ANGPT-1-HAE) or HAE of unknown origin (U-HAE) are bradykinin mediated, in which case future analysis of Bk-AE epidemiology should include these novel types. The gene discussed is PLG; the disease is hereditary angioedema.