ACE and angioedema: The weighted incidence of angioedema with ACE inhibitors was 0.30% (95% CI 0.28% to 0.32%) compared to 0.11% (95% CI 0.09 to 0.13) with ARBs, 0.13% (95% CI 0.08% to 0.19%) with DRIs, and 0.07% with placebo (95% CI 0.05 to 0.09).