For a country with 100 Million inhabitants there would be approximately 31,500 bradykinin mediated angioedema attacks each year, calculated by multiplying the prevalence standardized to 1 million, 150 for ACEI-AE, 15 per for C1-INH-HAE, and 1.5 for C1-INH-AAE, with 100 for each entity, and multiplying the resulting figures with an annual attack rate of approximately 1 per year for ACEI-AE and 10/year for C1-INH-HAE and C1-INH-AAE. Here, SERPING1 is linked to acquired angioedema.