Although some studies have not been able to demonstrate a positive correlation between the cfDNA level and tumor volume as measured by PET, some available research provides evidence that liquid biopsy can help determine tumor burden and has significant prognostic value because of its ability to detect KRAS, FAM123B, ARID1A, BRAF, and EGFR mutations [64–66]. The gene discussed is AMER1; the disease is neoplasm.