We further examined the expression of PD‐L1 in lung cancer tissues and A549/DDP cells (Cisplatin‐resistant human lung cancer cells), and found that PD‐L1 was up‐regulated significantly in patients who are chemoresistant (P < .001, Figure 7C), the characteristics are shown in Table 1, and the expression of PD‐L1 in A549/DDP cells was higher than that of A549 cells and A549‐miR‐3127‐5p transduced cells, A549‐miR‐3127‐5p knocked down cells (P < .001, Figure 8A,B,C). The gene discussed is CD274; the disease is lung cancer.