We genotyped 296 SNPs in CYP2R1, CYP27A1, CYP27B1, CYP24A1, and VDR and observed associations between 27 SNPs and lung cancer status after the adjustment for age, gender, and race, all of which had passed the Hardy–Weinberg equilibrium assessment (Table S6). The gene discussed is CYP27A1; the disease is lung cancer.