Fiaf is also involved in the mechanism linking the microbiome to NAFLD, where dysbiotic microbiota inhibits Fiaf secretion from intestinal cells and leads to activation of LPL, carbohydrate-responsive element binding protein, (ChREBP) and sterol regulatory element-binding protein 1(SREBP-1), and subsequent triglyceride accumulation in the liver (Backhed et al., 2004). The gene discussed is MLXIPL; the disease is metabolic dysfunction-associated steatotic liver disease.