IgA nephropathy (IgAN) is a common glomerular pathology that frequently causes renal failure, especially in young people.1, 2 IgAN is characterized by glomerular deposits of galactose-deficient IgA1.3, 4 Although a 4-hit theory is proposed for mesangial IgA deposition,5 the mechanisms leading to glomerular injury remain poorly understood. This evidence concerns the gene IGHA1 and IgA glomerulonephritis.