The general procedure for autologous TIL therapy is stated as follows: (1) the resected melanoma is digested into fragments; (2) each fragment is grown in IL-2 and the lymphocytes proliferate destroying the tumor; (3) after a pure population of lymphocytes exists, these lymphocytes are expanded; and (4) after expansion up to 1011 cells, lymphocytes are infused into the patient (Figure 2(a)) [66]. Here, IL2 is linked to melanoma.